A verb that means to separate something or someone from another thing or person. In another context, alienate might also mean handing over an asset or property to a new owner who might have bought it.

Jeff Bridges, whose turn as the Dude in "The Big Lebowski" gave him instant cult status, has joined the cast of "How to Lose Friends and Alienate People" alongside "Spider-Man" star Kirsten Dunst and ...