Cryo-EM reconstructions of the human ATR–ATRIP complex show how clinical small-molecule inhibitors like VE-822 and RP-3500 bind to and inhibit ATR activity. A research team led by Prof. Gang Cai and ...

Proteins are the molecular workhorses of cells. To understand their functions, scientists soon realized that they had to figure out proteins’ shapes. But solving a protein structure is a challenging ...

This study systematically elucidates the multifunctional transport properties and structural basis of BTR1, a member of the SLC4 family. Using cryo-electron microscopy (cryo-EM) and electrophysiology, ...

Chemerin is a key adipokine that regulates lipid metabolism and insulin sensitivity, and thus is involved in many metabolic diseases such as obesity and diabetes. In addition, it plays a critical role ...

Biological motors, which aid microorganism movement in fluids, are composed of two components -- the rotor and stators. Despite much research, the exact molecular mechanism underlying stator function ...