Nature

Comparison of the effectiveness of different normalization methods for metagenomic cross-study phenotype prediction under heterogeneity

The human microbiome, comprising microorganisms residing within and on the human body, plays a crucial role in various physiological processes and has been linked to numerous diseases. To analyze ...
Nature

Synthetic data generation for a longitudinal cohort study – evaluation, method extension and reproduction of published data analysis results

In biomedical research, scientific progress is often limited by the availability and quality of data. The results of any study can only be as good as the data on which the statistical analysis was ...

Hidden geometry explains why kernel methods separate complex data so well

Are two sets of data genuinely different, or is it because of randomness? This question, known as the two-sample testing ...
ascopubs.org

Performance of Two-Phase Designs for the Time-to-Event Outcome and a Case Study Assessing the Relapse Risk Associated With B-ALL Subtypes

As biomarker studies employ increasingly complex and expensive genomics and other correlative methods, it is increasingly important to rigorously design these studies and analyze the downstream ...