Germline and somatic variants are inherently connected. All germline variants originate as de novo somatic mutations either in parental germ cells or very early in embryonic development. As such, ...

A genetic difference carried by nearly one in three people may increase the risk of severe COVID-19 and lung fibrosis by disrupting the function of a previously unknown protein, according to a new ...

The great majority of how we understand human disease, and attempt to cure it, derives from mice genetically fashioned to be prolific breeders, docile and easy to handle—all qualities that have made ...

Genetic divergence and adaptive variation constitute the foundation of evolutionary change in natural populations. Divergence arises when populations accumulate distinct allele frequencies through ...

Structural variants (SVs) are alterations in the DNA sequence that involve large-scale changes, typically longer than 50 base pairs. Advances in long-read sequencing have significantly increased ...

Knowing how human DNA changes over generations is essential to estimating genetic disease risks and understanding how we evolved. But some of the most changeable regions of our DNA have been ...

Whole-genome research found that Cape Floristic Region leopards are smaller, genetically distinct, and isolated from other ...

For more than a century, Mendelian genetics has shaped how we think about inheritance: one gene, one trait. It is a model that still echoes through textbooks—and one that is increasingly reaching its ...

Nomic Bio Inc. announced a research collaboration with the Wellcome Sanger Institute to perform large-scale proteomic ...

A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University and institutions across the U.S.

Graft a patch of skin from one wild cheetah onto another, unrelated cheetah, and the recipient’s body will not reject it.

Gene editing may hold the key to rescuing endangered species—not just by preserving them, but by restoring their lost genetic diversity using DNA from museum specimens and related species. Scientists ...