Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

Advances in the ability to image cells and tissues have driven progress in cell and developmental biology, among other fields. Current developments in light microscopy research include volumetric and ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Light microscopy is a cornerstone in life sciences technology, having experienced considerable diversification since its inception. This development becomes visible when considering the distinctive ...

In biology, seeing can lead to understanding, and researchers in Professor Edward Boyden's lab at the McGovern Institute for Brain Research are committed to bringing life into sharper focus. With a ...

It is the computational processing of images that reveals the finest details of a sample placed under all kinds of different light microscopes. Even though this processing has come a long way, there ...

Overcoming the resolution limit in a light microscope of around half a wavelength of light (about 250 nanometers) is one of the most significant developments in optics. Due to the wave nature of light ...

Assistant Professor of Biomedical Engineering Yi Xue works on 2P-FOCUS, a new two-photon microscopy system, in her lab. The system promises novel insights into biological features that were once only ...

Our brain is a complex organ. Billions of nerve cells are wired in an intricate network, constantly processing signals, enabling us to recall memories or to move our bodies. Making sense of this ...

In 1931, physicists Knoll and Ruska unveiled the first electron microscope, revolutionizing science by using magnetic lenses to overcome the limits of visible light. This groundbreaking invention ...

From the advent of optical microscopes to today, light microscopy methods have been central to life science discoveries across disciplines. Scientists turn to light microscopy when imaging cells, ...