The multi-enzyme pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle and plays vital roles in metabolism, energy production, and cellular signaling. Although all components ...

Nascent chains undergo co-translational enzymatic processing as soon as their N-terminus becomes accessible at the ribosomal polypeptide tunnel exit (PTE). In eukaryotes, N-terminal methionine ...

University of Cincinnati Cancer Center researchers looked billions of years into the past to learn more about the potential future of precision medicine. Led by first author Bibek R. Karki and senior ...

For the first time, the structure of a DNA enzyme complex implicated in infertility and cancer has been obtained using cryo-electron microscopy (cryo-EM). A collaboration of researchers, led by ...

Although some small studies suggest that digestive enzymes may help reduce bloating and other gastrointestinal (GI) symptoms, there is not enough clinical evidence to support this. Digestive enzymes ...