Opioid use disorder (OUD) is a chronic relapsing disorder that is a major burden for the lives of affected individuals, and society as a whole. Opioid withdrawal is characterized by strong physical ...

Negative Affect Syndrome then emerges when individuals are unable to achieve an effective ratio of costs and benefits (i.e., they feel they can’t get their needs met) and they suffer as a consequence.

Heightened negative affect is a core feature of serious mental illness. Over 90% of American adults own a smartphone, equipped with an array of sensors which can continuously and unobtrusively measure ...