Animal models are established, important tools for preclinical safety and efficacy testing. Companies are advancing more “humanized” models to better reflect human responses, while at the same time ...
EB612, a first-in-class long-acting PTH(1-34) oral peptide for hypoparathyroidism, produced robust bioavailability and ...
Leptomeningeal disease (LMD) is a subtype of central nervous system metastatic disease that is associated with poor patient outcomes and limited treatment options. There is an unmet need to develop ...
Many drugs still fail after promising preclinical results, raising difficult questions about how disease is modelled in the ...
Pancreatic cancer (PC) is an aggressive malignant disease with poor prognosis, often diagnosed late, progressing rapidly, and resistant to chemotherapy. Although small molecule inhibitors (SMIs) show ...
A carefully designed metal-free carbon monoxide prodrug may help prevent some of the deadliest forms of cancer from spreading, according to researchers at Weill Cornell Medicine.
Zymeworks presents six posters at AACR highlighting advancements in antibody-drug conjugates and T cell engagers, including ZW209's promise in lung cancer. Zymeworks Inc. announced the presentation of ...
A new study from RCSI University of Medicine and Health Sciences demonstrates a novel approach in anticancer vaccine ...
The power of CRISPR became definitively clear when the first CRISPR-based gene therapy, Casgevy (exa-cel), won regulatory approvals for the treatment of sickle cell disease. But CRISPR’s applications ...
Cardiovascular–kidney–metabolic (CKM) syndrome is increasingly recognised as asystemic condition yet preclinical research still tends to treat heart, kidney andmetabolism as separate domains. A new ...
In the UK, there was a case where TGN1412, an immunotherapy under development, triggered a cytokine storm within hours of administration to humans, leading to multiple organ failure. Another example, ...
JW Pharmaceutical highlighted the therapeutic potential of DDC-02 in multiple neurodevelopmental disorder models at WODC USA ...
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