AID-induced U/G lesions can be perfectly repaired or may result in C/G transition mutations via DNA replication, C/G transition or transversion mutations via the BER pathway, and A/T mutations via the ...
The clustered regularly interspaced short palindromic repeats (CRISPR)–Cas system was repurposed for nuclease editing, base editing (BE) and prime editing 1. Among these methods, BE can efficiently ...