The term ‘bioavailability’ refers to how much of a drug actually reaches the bloodstream. Oral bioavailability, the bioavailability of drugs that are swallowed or otherwise delivered into the stomach, ...

Background and Objective: Narcotic analgesics such as hydromorphone undergo an extensive first-pass effect resulting in a low systemic bioavailability following oral administration. Alternative dosing ...

Sequences of topotecan and cisplatin: phase I, pharmacologic, and in vitro studies to examine sequence dependence. Twelve patients with refractory solid tumors were enrolled onto this three-period ...

Absorption, distribution, metabolism, and excretion (ADME) are four main processes that demonstrate how a drug behaves after being administered. Therefore, ADME is key in defining a compound’s ...