Synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD), must be tightly regulated to prevent saturation, which would impair learning. Metaplasticity mechanisms have ...
In this study, the authors find that SHANK3’s large intrinsically disordered region mediates phase separation to support postsynaptic density remodeling during long-term potentiation, providing an ...
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